Faculty: Matthew Kay
  
Matthew Kay

 
  Research
Selected Publications
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Research

My research interest is to understand the spatiotemporal dynamics of cardiac electrical activity during normal and disease conditions – with an overall goal of improving heart disease therapies. Fluorescence and electrical imaging of animal hearts (ex-vivo) and two and three dimensional cultures of cardiac cells (in-vitro) is used with custom image and signal processing algorithms to test hypotheses and identify mechanisms of cardiac electrical pathologies. Recent projects have investigated the role of rotor formation in maintaining ventricular fibrillation, electrical vorticity during atrial fibrillation, mechanisms of anti-tachycardia pacing in rabbit hearts and cell cultures, the effect of tissue structure on electrical conduction, and the role of regional ischemia on the induction of ventricular fibrillation.

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Selected Publications

  • Gillum N, Karabekian Z, Swift LM, Brown RP, Kay MW, Sarvazyan NA. Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium. Toxicol. Appl. Pharmacol., in press 2009.
  • Kay MW, Swift LM, Martell BS, Arutunyan A, Sarvazyan NA. Location of ectopic beats coincides with spatial gradients of NADH in a regional model of low-flow reperfusion. Am. J. Physiol. Heart Circ. Physiol., 294: H2400-H2405, 2008.
  • Swift LM, Martell BS, Khatri V, Arutunyan A, Sarvazyan NA, Kay MW. Controlled regional hypoperfusion in Langendorff heart preparations. Physiological Measurement, 29: 269-279, 2008.
  • Rogers JM, Walcott GP, Gladden JD, Melnick SB, Ideker RE, Kay MW.
    Epicardial wavefronts arise from widely distributed transient sources
    during ventricular fibrillation in the isolated swine heart. New J.
    Physics, 10 (015004): 1-12, 2008.
  • Agladze KI, Kay MW, Krinsky VI, Sarvazyan NA. Interaction between spiral and paced waves in cardiac tissue. 2007. Am. J. Physiol. Heart Circ. Physiol., 293: 503-513, 2007.
  • Khatri V, Manuccia T, Kay M. Design of a mechanomyogram to monitor muscle fatigue. Intl. J. Med. Impl. Dev., 2007.
  • Rogers JM, Walcott GP, Gladden JD, Melnick SB, Kay MW. Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart. Biophys J. 2007; 92(3):1090-5.
  • Byrd IA, Kay MW, Pollard AE. Interactions between paced wavefronts and monomorphic ventricular tachycardia: implications for antitachycardia pacing. J Cardiovasc Electrophysiol. 2006, 17(10):1129-39.
  • Schuessler RB, Kay MW, Melby SJ, Branham BH, Boineau JP, Damiano RJ Jr. Spatial and temporal stability of the dominant frequency of activation in human atrial fibrillation. J. Electrocardiol. 2006, 39(4 Suppl):S7-12.
  • Kay MW, Walcott GP, Gladden JD, Melnick SB, Rogers JM. Lifetimes of epicardial rotors in panoramic optical maps of fibrillating swine ventricles. Am J Physiol Heart Circ Physiol. 2006, 291(4):H1935-41.
  • Kay MW, Gray RA. Measuring curvature and velocity vector fields for waves of cardiac excitation in 2D media. IEEE Trans. Biomed. Eng., 52(1): 50-63, 2005.
  • Kay MW, Amison PM, Rogers JM. Three-dimensional surface
    reconstruction and panoramic optical mapping of large hearts. IEEE
    Trans. Biomed. Eng., 51(7): 1219-1229, 2004.

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Assistant Professor of Engineering and Applied Science,
Assistant Professor of Pharmacology and Physiology
Office: Phillips Hall 619
Phone: 202-994-6083, Fax: 202 994-0227

Lab: Ross Hall 456
Lab Phone: 202-994-0621
Email: phymwkATgwu.edu

B.S.M.E. 1993, North Carolina State University, NC
M.S.B.E. 1996, North Carolina State University, NC
D.S.B.M.E. 2000, Washington University in St. Louis, MO